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<i>Drosophila melanogaster</i> lactate dehydrogenase deficiency recapitulates the exercise intolerance of human glycogen storage disease type XI

2026-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme that commonly exhibits altered expression in human diseases such as cancers and neurodegeneration, making it a valuable disease biomarker and putative therapeutic target. However, any treatment targeting LDHA will also disrupt normal metabolism, underscoring the need to investigate physiological consequences of inhibiting this enzyme. We...

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Literature Corpus work
8ba7f7b1-d568-57b5-8ad7-d3202d956883
DOI
10.64898/2026.07.09.736989
Open publication

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