Article

Muscle Energy Crisis is the Initial Driver of Locomotor Dysfunction in β-glucuronidase-Deficient <i>Drosophila</i>

2025-10-26

Abstract excerpt

Mucopolysaccharidosis type VII (MPS VII) is characterised by progressive locomotor decline, attributed to musculoskeletal and neurological defects. However, the severity varies according to the extent of β-glucuronidase (β-GUS) deficiency, with musculoskeletal deformities typically preceding neurological manifestations. To investigate the underlying cause of neuromuscular pathology, we employed β-GUS-deficient Dr...

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Literature Corpus work: 606962a8-dbfe-5446-9610-ad00901a0a43
DOI: 10.1101/2025.10.25.684497

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