Article
CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III.
Communications biology - 23 Jan 2026
Daghar Hiba, Pyman Blake, Maios Claudia, Doyle James, Perlstein Ethan, Samarut Éric, Parker J Alex
Abstract excerpt
Glycogen Storage Disease Type III (GSDIII) is a rare genetic disorder caused by mutations in the AGL gene, leading to a deficiency in the glycogen debranching enzyme. This results in the accumulation of abnormal glycogen in various tissues, causing a range of symptoms, including liver enlargement and hypoglycemia. Current animal models do not fully recapitulate the severe phenotypes observed in patients,...
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