Article
Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.
JCI insight - 22 Mar 2022
Mortberg Meredith A, Zhao Hien T, Reidenbach Andrew G, Gentile Juliana E, Kuhn Eric, O'Moore Jill, Dooley Patrick M, Connors Theresa R, Mazur Curt, Allen Shona W, Trombetta Bianca A, McManus Alison, Moore Matthew R, Liu Jiewu, Cabin Deborah E, Kordasiewicz Holly B, Mathews Joel, Arnold Steven E, Vallabh Sonia M, Minikel Eric Vallabh
Abstract excerpt
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factors, we developed and validated a plate-based immunoassay reactive for PrP across 6 species of interest and applicable...
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