Article

PrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact

2021-11-01

Abstract excerpt

Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factors, we developed and validated a plate-based immunoassay reactive for PrP across six species of interest and applicabl...

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Literature Corpus work: 625154e9-2a6c-57b9-a9f4-3974b234fffd
DOI: 10.1101/2021.11.01.21265619

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