Article

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

2023-11-30

Abstract excerpt

<h4>Summary</h4> ZMYND11 encodes an epigenetic reader of histone methylation, functioning as a transcriptional corepressor. However, whether and how ZMYND11 contributes to cancer progression and therapy remains unclear. Here we report that ZMYND11 downregulation is prevalent in cancers and profoundly correlates with adverse prostate cancer patient outcomes. Depletion of ZMYND11 promotes tumor cell growth, migrati...

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Literature Corpus work: 394c6ba1-54c6-5097-af99-c09d4f36497c
DOI: 10.1101/2023.11.28.569112

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