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Article

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

22 Jul 2015

Abstract excerpt

DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progression. DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex...

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Identifiers

PMID: 26199140
DOI: 10.1038/ncomms8821

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DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progressionPMID 26199140Read ↗

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene TranscriptionSemantic proximity Read ↗

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell LymphomaSemantic proximity Read ↗

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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Semantic proximity Read ↗

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatinSemantic proximity Read ↗

miR-133b suppresses colorectal cancer cell stemness and chemoresistance by targeting methyltransferase DOT1LSemantic proximity Read ↗

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL OncogenesSemantic proximity Read ↗

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancerSemantic proximity Read ↗

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphomaSemantic proximity Read ↗

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.Semantic proximity Read ↗

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An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC developmentSemantic proximity Read ↗

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