Article

Sobp modulates Six1 transcriptional activation and is required during craniofacial development

2021-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, craniofacial and/or renal defects. Mutations in the transcription factor Six1 and its cofactor Eya1, both required for otic development, are linked to BOR. We previously identified Sobp as a potential Six1 cofactor and SOBP mutations in mouse and humans cause otic phenotypes; therefore, we asked whether Sobp interact...

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Literature Corpus work: 8286df34-b3a0-5513-b988-ff1a836912fe
DOI: 10.1101/2021.04.05.438472

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