Article

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

2023-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and aims</h4> Capsid assembly (CA) is a critical step in the hepatitis B virus (HBV) life cycle, mediated by the viral core protein. CA is the target for various new anti-viral candidate therapeutics known as capsid assembly modulators (CAMs) of which the CAM-aberrant (CAM-A) class induces aberrant shaped core protein structures and lead to hepatocyte cell death. The aim of the s...

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Literature Corpus work: 8b65a256-0c8c-5730-a6e3-ded087bb2c0f
DOI: 10.1101/2023.09.25.559252

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Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translationDOI 10.1101/2023.09.25.559252Read

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