Article

A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B

2024-07-16

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is strongly associated with increased risk of liver cancer and cirrhosis. While existing treatments effectively inhibit the HBV life cycle, viral rebound occurs rapidly following treatment interruption. Consequently, functional cure rates of chronic HBV infection remain low and there is increased interest in a novel treatment modality, capsid assembly modulators (CAMs). He...

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Literature Corpus work: 616de8bd-771e-5e90-b545-878d7c9524e3
DOI: 10.1101/2024.07.16.603658

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