Article
Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015
Ebert Gregor, Preston Simon, Allison Cody, Cooney James, Toe Jesse G, Stutz Michael D, Ojaimi Samar, Scott Hamish W, Baschuk Nikola, Nachbur Ueli, Torresi Joseph, Chin Ruth, Colledge Danielle, Li Xin, Warner Nadia, Revill Peter, Bowden Scott, Silke John, Begley C Glenn, Pellegrini Marc
Abstract excerpt
Hepatitis B virus (HBV) infection can result in a spectrum of outcomes from immune-mediated control to disease progression, cirrhosis, and liver cancer. The host molecular pathways that influence and contribute to these outcomes need to be defined. Using an immunocompetent mouse model of chronic HBV infection, we identified some of the host cellular and molecular factors that impact on infection outcomes. Here,...
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