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Article

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Gastroenterology - 1 Feb 2018

Klumpp Klaus, Shimada Takashi, Allweiss Lena, Volz Tassilo, Lütgehetmann Marc, Hartman George, Flores Osvaldo A, Lam Angela M, Dandri Maura

Abstract excerpt

BACKGROUND & AIMS: NVR3-778 is a capsid assembly modulator in clinical development. We determined the in vivo antiviral efficacy and effects on innate and endoplasmic reticulum (ER) stress responses of NVR3-778 alone or in combination with pegylated interferon alpha (peg-IFN) and compared with entecavir. METHODS: We performed 2 studies, with a total of 61 uPA/SCID mice with humanized livers. Mice were infected...

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Identifiers

PMID: 29079518
DOI: 10.1053/j.gastro.2017.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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