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Article

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).

Journal of medicinal chemistry - 26 Jul 2018

Vandyck Koen, Rombouts Geert, Stoops Bart, Tahri Abdellah, Vos Ann, Verschueren Wim, Wu Yiming, Yang Jingmei, Hou Fuliang, Huang Bing, Vergauwen Karen, Dehertogh Pascale, Berke Jan Martin, Raboisson Pierre

Abstract excerpt

Small molecule induced hepatitis B virus (HBV) capsid assembly modulation is considered an attractive approach for new antiviral therapies against HBV. Here we describe efforts toward the discovery of a HBV capsid assembly modulator in a hit-to-lead optimization, resulting in JNJ-632, a tool compound used to further profile the mode of action. Administration of JNJ-632 (54) in HBV genotype D infected chimeric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29906396
DOI: 10.1021/acs.jmedchem.8b00654

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