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Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles

27 Sept 2023

Abstract excerpt

ABSTRACT Capsid assembly modulators (CAMs) are a novel class of therapeutic small molecules with the potential to address the continued global challenge posed by chronic hepatitis B (CHB). Class A CAMs (CAM-As) are particularly attractive because they induce loss of hepatitis B virus (HBV)-infected hepatocytes in animal models. All CAM-As described to date are heteroaryldihydropyrimidines (HAPs) which come with...

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PMID: 37754761
DOI: 10.1128/jvi.00722-23

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