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Article

Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus.

Antiviral research - 1 Nov 2024

Lam Angela M, Mani Nagraj, Ardzinski Andrzej, Stever Kim, Cuconati Andrea, Micolochick Steuer Holly, Thi Emily P, Graves Ingrid E, Espiritu Christine L, Mesaros Eugen, Kultgen Steven G, Fan Kristi, Cole Andrew G, Harasym Troy O, Rijnbrand Rene, Brown Joanne, Eley Timothy, Varughese Tilly, Gane Edward, Picchio Gaston, Sims Karen D, Sofia Michael J

Abstract excerpt

HBV capsid assembly modulators (CAMs) target the core protein and inhibit pregenomic RNA encapsidation and viral replication. HBV CAMs also interfere with cccDNA formation during de novo infection, which in turn suppresses transcription and production of HBV antigens. In this report, we describe the antiviral activities of AB-836, a potent and highly selective HBV CAM. AB-836 inhibited viral replication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39326502
DOI: 10.1016/j.antiviral.2024.106010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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