Article

Analysis of the CD4+ T cell immune response to Anthrax Lethal Factor

2012-01-01

Abstract excerpt

The Gram-positive bacterium Bacillus anthracis is the causative agent of the potentially fatal illness, anthrax. A major determinant of B. anthracis pathogenicity is a binary toxin composed of Protective Antigen (PA) and one of two subunits; Lethal Factor (LF) or Edema Factor (EF). Translocation by PA into the host cell cytosol allows LF, which is a zinc metalloprotease, to inactivate the mitogen-activated protein...

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Literature Corpus work: 8b62508a-00a5-51ec-892e-ebec7ef90d31
DOI: 10.25560/9465

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