Article

HLA class II polymorphism influences the immune response to protective antigen and susceptibility to <i>Bacillus anthracis</i>

2019-11-13

Abstract excerpt

The causative agent of anthrax, Bacillus anthracis , evades the host immune response and establishes infection through the production of binary exotoxins composed of Protective Antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). The majority of vaccination strategies have focused upon the antibody response to the PA subunit. We have used a panel of humanised HLA class II transgenic mous...

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Literature Corpus work: a40ff258-fa0c-5caa-b192-7ccf422d64c3
DOI: 10.1101/841429

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