Article

Female specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and Estrogen Receptor α

2023-08-10

Abstract excerpt

<h4>Summary</h4> Autism manifests differently in males and females and the brain mechanisms that mediate these sex-dependent differences are unknown. Here, we demonstrate that deletion of the ASD-risk gene, Pten, in neocortical pyramidal neurons (NSE Pten KO) results in robust hyperexcitability of local neocortical circuits in female, but not male, mice, observed as prolonged, spontaneous persistent activity st...

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Literature Corpus work: 8b423e88-464d-54dc-a1db-5684b3d89e17
DOI: 10.1101/2023.08.10.552857

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Female specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and Estrogen Receptor αDOI 10.1101/2023.08.10.552857Read

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