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Article

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.

Molecular psychiatry - 1 Jan 2016

Tilot A K, Bebek G, Niazi F, Altemus J B, Romigh T, Frazier T W, Eng C

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, genetic component. Germline mutations in the tumor suppressor Pten are a well-established risk factor for ASD with macrocephaly, and conditional Pten mouse models have impaired social behavior and brain development. Some mutations observed in patients disrupt the normally balanced nuclear-cytoplasmic localization of...

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Autism Spectrum Disorder
Cerebral Cortex
Cohort Studies
Mice, Transgenic
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PTEN Phosphohydrolase

Sequence Analysis, RNA

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PMID: 25754085
DOI: 10.1038/mp.2015.17
PMCID: PMC4565786

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