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Article

Pten regulates neuronal arborization and social interaction in mice.

Neuron - 4 May 2006

Kwon Chang-Hyuk, Luikart Bryan W, Powell Craig M, Zhou Jing, Matheny Sharon A, Zhang Wei, Li Yanjiao, Baker Suzanne J, Parada Luis F

Abstract excerpt

CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. In the present study, we deleted Pten in limited differentiated neuronal populations in...

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Source

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Identifiers

PMID: 16675393
DOI: 10.1016/j.neuron.2006.03.023
PMCID: PMC3902853

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Pten regulates neuronal arborization and social interaction in mice.PMID 16675393Read ↗

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