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Article

Pten regulates neuronal arborization and social interaction in mice.

Neuron - 4 May 2006

Kwon Chang-Hyuk, Luikart Bryan W, Powell Craig M, Zhou Jing, Matheny Sharon A, Zhang Wei, Li Yanjiao, Baker Suzanne J, Parada Luis F

Abstract excerpt

CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in individuals with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. In the present study, we deleted Pten in limited differentiated neuronal populations in...

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Dendrites
Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta
Hypertrophy
Nervous System Malformations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PTEN Phosphohydrolase

Reflex, Startle

Social Behavior

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Identifiers

PMID: 16675393
DOI: 10.1016/j.neuron.2006.03.023
PMCID: PMC3902853

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Pten regulates neuronal arborization and social interaction in mice.PMID 16675393Read ↗

PTEN signaling in autism spectrum disorders.Semantic proximity Read ↗

Connecting Genotype with Behavioral Phenotype in Mouse Models of Autism Associated with PTEN Mutations.Semantic proximity Read ↗

The impact of phosphorylated Pten at threonine 366 on cortical connectivity and behaviourSemantic proximity Read ↗

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated -Catenin SignalingSemantic proximity Read ↗

Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.Semantic proximity Read ↗

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.Semantic proximity Read ↗

The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.Semantic proximity Read ↗

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.Semantic proximity Read ↗

Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.Semantic proximity Read ↗

Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth.Semantic proximity Read ↗

Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.Semantic proximity Read ↗

Germline Nuclear-predominant Pten Murine Model Exhibits Impaired Social and Perseverative Behavior, Microglial Activation, and Increased Oxytocinergic ActivitySemantic proximity Read ↗

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