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Article

The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.

Cell reports - 12 May 2015

Vogt Daniel, Cho Kathleen K A, Lee Anthony T, Sohal Vikaas S, Rubenstein John L R

Abstract excerpt

Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, we investigate the function of Pten in cortical GABAergic neurons using conditional mutagenesis in mice. Loss of Pten results in a preferential loss of SST(+) interneurons, which increases the ratio of parvalbumin/somatostatin (PV/SST) interneurons, ectopic PV(+) projections in layer I, and inhibition onto...

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Cell Shape
GABAergic Neurons
Interneurons
Interpersonal Relations
Neural Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyramidal Cells

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Identifiers

PMID: 25937288
DOI: 10.1016/j.celrep.2015.04.019
PMCID: PMC4431948

Genes

PTEN
SST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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