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Dissemination and Mechanism for the MCR-1 Colistin Resistance

28 Nov 2016

Abstract excerpt

Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new...

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PMID: 27893854
DOI: 10.1371/journal.ppat.1005957

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