Article

The fitness landscape of the mobilized colistin resistance gene <i>mcr-1</i>

2022-07-22

Abstract excerpt

The emergence and global discovery of the mobilized colistin resistance gene, mcr-1 , limits the clinical effectiveness of colistin as last-resort antibiotic against multiple-drug resistant bacteria. Although MCR-1 exhibits low levels of colistin resistance in E. coli , it is currently unknown whether mcr-1 may potentially evolve a high level of colistin resistance in the future. Here, we generated mcr-1 mutan...

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Literature Corpus work: 2d113b0e-3b8e-500b-b600-02f1fa25c242
DOI: 10.1101/2022.07.21.500813

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