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Article

Transferability of MCR-1/2 Polymyxin Resistance: Complex Dissemination and Genetic Mechanism

3 Feb 2018

Abstract excerpt

Polymyxins, a group of cationic antimicrobial polypeptides, act as a last-resort defense against lethal infections by carbapenem-resistant Gram-negative pathogens. Recent emergence and fast spread of mobilized colistin resistance determinant mcr-1 argue the renewed interest of colistin in clinical therapies, threatening global public health and agriculture production. This mini-review aims to present an updated...

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PMID: 29397687
DOI: 10.1021/acsinfecdis.7b00201

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