Article

Mechanistic Insights into Crosstalk of Tet(X) and MCR-1, Two Resistance Enzymes Co-produced by A Single Plasmid

2020-03-08

Abstract excerpt

Tigecycline and colistin are few of last-resort defenses used in anti-infection therapies against carbapenem-resistant bacterial pathogens. The successive emergence of plasmid-borne tet (X) tigecycline resistance mechanism and mobile colistin resistance ( mcr ) determinant, renders them clinically ineffective, posing a risky challenge to global public health. Here, we report that co-carriage of tet (X6) and mc...

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Literature Corpus work: 2a0c5d9e-d10f-5dbc-9614-e59ca6e20d11
DOI: 10.1101/2020.03.06.981738

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Mechanistic Insights into Crosstalk of Tet(X) and MCR-1, Two Resistance Enzymes Co-produced by A Single PlasmidDOI 10.1101/2020.03.06.981738Read

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