Article

Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations

2026-04-09

Abstract excerpt

The cellular form of the prion protein (PrP C ) is known for its involvement in the pathogenesis of prion diseases. Recent research implicates the physiological isoform of PrP in neuronal development, excitability, and synaptic plasticity, as well as in other biological processes. However, its precise function in the development and function of neurons remains poorly understood. Here, we investigated its role dur...

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Literature Corpus work: 8b2e4112-a6cd-5473-a385-3379e58e5a18
DOI: 10.64898/2026.04.07.716931

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