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Article

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.

Nature genetics - 1 Feb 1995

Whittington M A, Sidle K C, Gowland I, Meads J, Hill A F, Palmer M S, Jefferys J G, Collinge J

Abstract excerpt

The prion protein (PrP) is central to the aetiology of the prion diseases, transmissible neurodegenerative conditions of humans and animals. PrP null mice show abnormalities of synaptic neurophysiology, in particular weakened GABAA receptor-mediated fast inhibition and impaired long-term potentiation in the hippocampus. Here we demonstrate that this PrP null phenotype is rescued in mice with a high copy number of...

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Identifiers

PMID: 7719349
DOI: 10.1038/ng0295-197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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