Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.

doi:10.1038/ng0295-197

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Article

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.

Nature genetics - 1 Feb 1995

Whittington M A, Sidle K C, Gowland I, Meads J, Hill A F, Palmer M S, Jefferys J G, Collinge J

Abstract excerpt

The prion protein (PrP) is central to the aetiology of the prion diseases, transmissible neurodegenerative conditions of humans and animals. PrP null mice show abnormalities of synaptic neurophysiology, in particular weakened GABAA receptor-mediated fast inhibition and impaired long-term potentia...

Topics

Animals
Base Sequence
Humans
Male
Mice
Mice, Mutant Strains
Mice, Transgenic
Molecular Sequence Data
Neurophysiology
Phenotype
Prion Diseases
Prions

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