Article
Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.
Neurobiology of disease - 1 Jul 2013
Fleisch Valerie C, Leighton Patricia L A, Wang Hao, Pillay Laura M, Ritzel R Gary, Bhinder Ganive, Roy Birbickram, Tierney Keith B, Ali Declan W, Waskiewicz Andrew J, Allison W Ted
Abstract excerpt
The function of the cellular prion protein (PrP(C)) in healthy brains remains poorly understood, in part because Prnp knockout mice are viable. On the other hand, transient knockdown of Prnp homologs in zebrafish (including two paralogs, prp1 and prp2) has suggested that PrP(C) is required for CNS development, cell adhesion, and neuroprotection. It has been argued that zebrafish Prp2 is most similar to mammalian...
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