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Article

Olfactory behavior and physiology are disrupted in prion protein knockout mice.

Nature neuroscience - 1 Jan 2009

Le Pichon Claire E, Valley Matthew T, Polymenidou Magdalini, Chesler Alexander T, Sagdullaev Botir T, Aguzzi Adriano, Firestein Stuart

Abstract excerpt

The prion protein PrP(C) is infamous for its role in disease, but its normal physiological function remains unknown. Here we found a previously unknown behavioral phenotype of Prnp(-/-) mice in an odor-guided task. This phenotype was manifest in three Prnp knockout lines on different genetic back...

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Identifiers

PMID: 19098904
DOI: 10.1038/nn.2238
PMCID: PMC2704296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19098904-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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