Article

Membrane-anchored PrP <sup>Sc</sup> is the trigger for prion synaptotoxicity

2025-07-16

Abstract excerpt

<h4>ABSTRACT</h4> The mechanism by which prions composed of PrP Sc cause the neuropathological aberrations characteristic of prion diseases remains elusive. Previous studies have defined a synaptotoxic signaling pathway in which extracellular PrP Sc stimulates NMDA receptor-mediated Ca 2+ influx, activation of p38 MAPK, and collapse of the actin cytoskeleton in dendritic spines, resulting in functional decreme...

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Literature Corpus work: fe78133b-d71b-5f51-8693-850c7f702e1b
DOI: 10.1101/2025.07.11.664221

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