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Article

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

1 Oct 2019

Abstract excerpt

Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants is associated with permanent neurological sequelae in 9 million infants every year. Investigating the regulators of microglial activation in the developing brain across models of...

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Share to Neonatal and fetal brain pathology
Share to Neurogenesis and neuroplasticity mechanisms
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PMID: 31665242
DOI: 10.1093/brain/awz319

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