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ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex

13 Jun 2024

Abstract excerpt

The mammalian neocortex is formed by sequential radial migration of newborn excitatory neurons. Migrating neurons undergo a multipolar-to-bipolar transition at the subplate (SP) layer, where extracellular matrix (ECM) components are abundantly expressed. Here, we investigate the role of the ECM at the SP layer. We show that TGF-β signaling-related ECM proteins, and their downstream effector, p-smad2/3, are...

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PMID: 38871984
DOI: 10.1038/s44319-024-00174-x

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