Article

Network mapping identifies a shared APP-MAPT proteostasis convergence zone in Alzheimer's disease

2026-08-24

Abstract excerpt

<title>Abstract</title> <p>Amyloid-β and tau, the defining lesions of Alzheimer’s disease, both depend on proteostatic machinery for clearance. The proteostasis machinery common to APP and MAPT has not been mapped. Without reference to any disease dataset, we constructed a 990-protein proteostasis network spanning vesicular trafficking, autophagy, the ubiquitin-proteasome system, and molecular chaperones. Within...

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Literature Corpus work: 8b10ef09-de40-5f95-9f01-fdee6889d114
DOI: 10.21203/rs.3.rs-10716568/v1

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