Article

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

2024-03-28

Abstract excerpt

<title>Abstract</title> <p>The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (<italic>C9orf72</italic>, <ital...

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Literature Corpus work: 5f26b021-0671-5a3e-87aa-044e7fda5d2e
DOI: 10.21203/rs.3.rs-4103685/v1

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