Article

Proteomic Analysis in Alzheimer’s Disease with Psychosis Reveals Separate Molecular Signatures for Core AD Proteinopathy and Postsynaptic Density Disruption

2025-12-01

Abstract excerpt

<h4>Background: </h4> and Hypothesis: Alzheimer’s disease with psychosis (AD+P) is a subgroup of AD patients with more rapid cognitive deterioration. While our previous study showed that AD+P is associated with loss of prefrontal cortex postsynaptic density (PSD) proteins, identifying proteins in the broader cellular environment that influence PSD loss addresses a critical knowledge gap about synaptic dysfunction...

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Literature Corpus work: 59f2257e-71c0-52d8-ae67-7c1cc0d6f4d0
DOI: 10.1101/2025.11.26.690872

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