Article

Exploiting rodent cell blocks for intrinsic resistance to HIV-1 gene expression in human T cells

2023-04-08

Abstract excerpt

HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (Exportin-1, also known as CRM1), respectively. In human cells, Tat binds CCNT1 to enhance viral RNA transcription and Rev recruits XPO1 to mediate the nuclear export of intron-co...

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Literature Corpus work: 8aed610d-2b71-54a8-9a0d-8f90da059181
DOI: 10.1101/2023.04.08.536105

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