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Article

Multiple Blocks to Human Immunodeficiency Virus Type 1 Replication in Rodent Cells

1 Nov 2000

Abstract excerpt

The recent identification of human gene products that are required for early steps in the human immunodeficiency virus type 1 (HIV-1) life cycle has raised the possibility that rodents might be engineered to support HIV-1 infection. Therefore, we have examined the ability of modified mouse, rat, and hamster cell lines to support productive HIV-1 replication. Rodent cells, engineered to support Tat function by...

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PMID: 11024113
DOI: 10.1128/jvi.74.21.9868-9877.2000

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