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Article

HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific

9 Jan 2018

Abstract excerpt

ABSTRACT Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production, reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential host factors cyclin T1 (CCNT1) and exportin-1 (XPO1, also known as CRM1), respectively. To determine if mouse cell blocks other than CCNT1 and XPO1 affect HIV's postintegration stages, we studied HIV-1 NL4-3 gene...

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Identifiers

PMID: 29321323
DOI: 10.1128/jvi.02102-17

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