Article

Discordant restoration of TCR expression and function by CD247 somatic reversions

2025-04-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The CD247 chain of the T-cell receptor (TCR) is essential for normal T cell development and function. Reported CD247-deficient patients showed severe immunodeficiency despite the presence of two populations of peripheral T cells, most with low TCR levels carrying the germline variant and a few with higher TCR levels due to somatic reversion. However, the reverta...

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Literature Corpus work: e95ae186-7b3d-5329-b9a6-02fcf70eb292
DOI: 10.21203/rs.3.rs-5741291/v1

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