Article

The retrotransposon <i>-</i> derived capsid genes <i>PNMA1</i> and <i>PNMA4</i> maintain reproductive capacity

2024-05-14

Abstract excerpt

<h4>ABSTRACT</h4> The human genome contains 24 gag -like capsid genes derived from deactivated retrotransposons conserved among eutherians. Although some of their encoded proteins retain the ability to form capsids and even transfer cargo, their fitness benefit has remained elusive. Here we show that the gag -like genes PNMA1 and PNMA4 support reproductive capacity. Six-week-old mice lacking either Pnma1 or...

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Literature Corpus work: 48e15edb-8bdc-5426-9109-f4fda201d3f0
DOI: 10.1101/2024.05.11.592987

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