Article

Identification of CP77 as the third orthopoxvirus SAMD9L inhibitor with a unique specificity for a rodent SAMD9L

2019-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Orthopoxviruses (OPXVs) have a broad host range in mammalian cells, but Chinese hamster ovary (CHO) cells are non-permissive for vaccinia virus (VACV). Here, we revealed a species-specific difference in host restriction factor SAMD9L as the cause for the restriction and identified orthopoxvirus CP77 as a unique inhibitor capable of antagonizing Chinese hamster SAMD9L (chSAMD9L). Two known VACV i...

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Identifiers and source

Literature Corpus work: 6448fda6-6936-5778-9263-b21feeeaf911
DOI: 10.1101/551556

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