Article

Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndrome

2021-04-24

Abstract excerpt

Short tandem repeat (STR) instability is causally linked to pathologic transcriptional silencing in a subset of repeat expansion disorders. In fragile X syndrome (FXS), instability of a single CGG STR tract is thought to repress FMR1 via local DNA methylation. Here, we report the acquisition of more than ten Megabase-sized H3K9me3 domains in FXS, including a 5-8 Megabase block around FMR1 . Distal H3K9me3 domain...

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Identifiers and source

Literature Corpus work: 2a07fc35-1e17-550c-ba27-7db23da3a228
DOI: 10.1101/2021.04.23.441217

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