Article

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

2020-07-31

Abstract excerpt

The health of the kidney filtration barrier requires communication between podocytes, endothelial cells and mesangial cells. Disruption of these cell-cell interactions is thought to contribute to disease progression in chronic kidney diseases (CKD). We recently demonstrated that podocyte ablation via doxycycline-inducible deletion of an essential endogenous molecule, CTCF (iCTCF pod-/- ), is sufficient to drive p...

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Literature Corpus work: 5240f4b8-46f9-5934-9db1-170cf302544a
DOI: 10.1101/2020.07.30.229666

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