Back to search

Article

Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic <i>NF1</i> mutant glioblastoma

2024-07-03

Abstract excerpt

NF1 is recurrently mutated in glioblastoma yet the molecular landscape and efficacy of targeted therapies remain unclear. Here, we combine bulk and single cell genomics of human somatic NF1 mutant, IDH-wildtype glioblastomas with functional genomic analysis of cell lines and mouse intracranial tumor models to identify molecular subgroups within NF1 mutant glioblastomas and mechanisms underlying MEK inhibitor res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8ad01502-a6cf-5f1d-a674-f1e94c7fdfc6
DOI
10.1101/2024.07.01.601334
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic <i>NF1</i> mutant glioblastomaDOI 10.1101/2024.07.01.601334
Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1Semantic proximity
Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity
NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes.Semantic proximity
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1Semantic proximity
Direct <i>in vivo</i> mapping of functional suppressors in glioblastoma genomeSemantic proximity
Integrating genomic, transcriptomic and epigenetic data to identify phenotypically impactful driver pathways in glioblastomaSemantic proximity
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Semantic proximity
Multi-omic profiling identifies distinct MAPK-centric subgroups in BRAF- and PTPN11-mutant IDH-wildtype glioblastomaSemantic proximity
Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity
Functional profiling of murine glioma models highlights targetable immune evasion phenotypesSemantic proximity
The molecular landscape of glioma in patients with Neurofibromatosis 1Semantic proximity
Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumorsSemantic proximity
Select a neighboring publication to make it the new centre.