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Multi-omic profiling identifies distinct MAPK-centric subgroups in BRAF- and PTPN11-mutant IDH-wildtype glioblastoma

2026-04-24

Abstract excerpt

<title>Abstract</title> <p>Background The role of MAPK pathway alterations in IDH-wildtype glioblastoma remains incompletely defined, particularly for BRAF and PTPN11 mutations. Methods We performed an integrated analysis of publicly available glioblastoma datasets (n = 641; IDH-wildtype n = 588), including 25 BRAF-mutated, 22 PTPN11-mutated, and 537 double-wildtype tumors. Clinical, genomic, transcriptomic, an...

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Literature Corpus work
3528bb8d-aedf-557c-9899-e47a61e4583d
DOI
10.21203/rs.3.rs-9415669/v1
Open publication

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Multi-omic profiling identifies distinct MAPK-centric subgroups in BRAF- and PTPN11-mutant IDH-wildtype glioblastomaDOI 10.21203/rs.3.rs-9415669/v1
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