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Article

NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes.

Acta neuropathologica communications - 29 Oct 2024

Chang Michael, Sherief Mohamed, Ioannou Maria, Chinnasamy Viveka, Chen Lucy, Frost Michael, Mattson-Hoss Michelle, Sarnoff Herb, Kamson David O, Holdhoff Matthias, Mukherjee Debraj, Bettegowda Chetan, Rincon-Torroella Jordina, Croog Victoria, Huang Peng, Rodriguez Fausto J, Lucas Calixto-Hope G, Schreck Karisa C

Abstract excerpt

BACKGROUND: NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accurate and consistent detection of NF1 loss, however, is fraught given the large gene size, challenges with complete coverage and variant calling upon sequencing, and mechanisms...

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Aged
Brain Neoplasms
Cohort Studies
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Neurofibromin 1

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Open in PubMed Open full text

Identifiers

PMID: 39472976
DOI: 10.1186/s40478-024-01875-z
PMCID: PMC11520828

Genes

NF1
EGFR
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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