Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Abstract excerpt

The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/...

Topics

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• Glioma Diagnosis and Treatment
• Medical Imaging Techniques and Applications
• Radiopharmaceutical Chemistry and Applications

Identifiers and source

Literature Corpus work

ce879988-645a-5283-8a3c-0ef9611fc827

DOI

10.17615/7tss-5e39