Article

<i>In vivo</i> single-cell ribosome profiling reveals cell-type-specific translational programs during aging

2024-11-03

Abstract excerpt

Somatic stem cells are characterized by their low overall protein synthesis rates, a feature implicated in driving their stemness. However, how aging reshapes the translational landscape of stem cells and how these changes impact their regenerative capacity remains poorly understood. Here, we present an in vivo single-cell ribosome profiling strategy to monitor tissue-wide translational landscapes of the young an...

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Literature Corpus work: 8abb6e70-92ce-5375-aae4-7777edc6a968
DOI: 10.1101/2024.11.02.621639

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