Article

<i>In vivo</i> translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis

2017-01-26

Abstract excerpt

<h4>Background</h4> Genetic alterations impacting on ubiquitously expressed proteins involved in mRNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translational defects can contribute to disease. Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, whose role in disease pathogenesis remains unclear. <h4>Results</h4> By...

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Literature Corpus work: 95d68f6d-2d40-56a3-b82c-1bc275f1ee99
DOI: 10.1101/103481

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