Article

Renal Cl-/H+ antiporter ClC-5 regulates collagen production and release in Dent Disease models

2023-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the Cl - /H + antiporter ClC-5 cause Dent’s Disease 1 (DD1), a rare primary tubulopathy that eventually progresses to renal failure. In fact, even with normal kidney function, DD1 patients present renal tubulointerstitial fibrosis. However, the link between ClC-5 loss-of-function and renal fibrosis remains unclear. Here, we have shown that DD1 mice models lacking ClC-5 present hig...

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Literature Corpus work: f50e3221-c70f-57fc-9b59-02244ab01073
DOI: 10.1101/2023.04.21.537823

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